THE director Edward Zwick has faced many challenges in his career. For his Civil War drama, “Glory,” he built an entire fort on a Savannah, Ga., beach and then laid siege to it. While shooting his domestic terrorism thriller, “The Seige,” he shut down the Brooklyn Bridge for an entire day. But these pale, perhaps, before the latest challenge he has set for himself: persuading men to shell out for a romantic comedy. That’s what people are calling “Love and Other Drugs,” even if the label is a loose fit.

Adapted from Jamie Reidy’s best-selling memoir about the Viagra gold rush in the late 1990s, it stars Jake Gyllenhaal as a womanizing pharmaceutical representative who falls in lust, and then in love, with a beautiful young woman (Anne Hathaway) with Stage 1 Parkinson’s disease. It would be a plunge deep into disease-of-the-week territory, if not for the raunch — sex scenes, sex tapes, nudity, an orgy — that Mr. Zwick has seasoned the film with and that may leave some in the audience wondering whether they are watching a film about Viagra, or on Viagra.